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Huge viruses key to the evolution of the cell

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  • Huge viruses key to the evolution of the cell

    Source: https://scitechdaily.com/in-ancient-giant-viruses-lies-the-truth-medusavirus-key-to-deciphering-evolutionary-mystery/



    In Ancient Giant Viruses Lies the Truth: Medusavirus Key to Deciphering Evolutionary Mystery

    By TOKYO UNIVERSITY OF SCIENCE SEPTEMBER 11, 2020

    Evolutionary Mystery of Cell Nuclei
    DNA exchange between ancient giant viruses and ancient biological cells might have been the key to the evolution of nuclei in eukaryotic cells. Credit: Tokyo University of Science

    Giant viruses, like the recently discovered medusavirus, may hold the key to deciphering the evolutionary mystery of the eukaryotic nucleus.

    An exchange of genetic material that occurred when ancient giant viruses infected ancient eukaryotic cells could have caused the nucleus of the eukaryotic cell-its defining feature-to form. This is what Professor Masaharu Takemura of the Tokyo University of Science, Japan, suggests in his recent review in the journal Frontiers in Microbiology. His novel evolutionary hypothesis opens doors to new discussions on the subject, bringing us one giant step closer to the truth.

    Perhaps as far back as the history of research and philosophy goes, people have attempted to unearth how life on earth came to be. In the recent decades, with exponential advancement in the fields of genomics, molecular biology, and virology, several scientists on this quest have taken to looking into the evolutionary twists and turns that have resulted in eukaryotic cells, the type of cell that makes up most life forms today.

    The most widely accepted theories that have emerged state that the eukaryotic cell is the evolutionary product of the intracellular evolution of proto-eukaryotic cells, which were the first complex cells, and symbiotic relationships between proto-eukaryotic cells and other unicellular and simpler organisms such as bacteria and archaea. But according to Professor Masaharu Takemura of the Tokyo University of Science, Japan, “These hypotheses account for and explain the driving force and evolutionary pressures. But they fail to portray the precise process underlying eukaryotic nucleus evolution.”

    Prof Takemura cites this as his motivation behind his recent article published in Frontiers in Microbiology, where he looks into the recent theories that, in addition to his own body of research, have built up his current hypothesis on the subject.

    In a way, Prof Takemura’s hypothesis has its roots in 2001 when, along with PJ Bell, he made the revolutionary proposal that large DNA viruses, like the poxvirus, had something to do with the rise of the eukaryotic cell nucleus. Prof Takemura further explains the reasons for his inquiry into the nucleus of the eukaryotic cell as such: “Although the structure, function, and various biological functions of the cell nucleus have been intensively investigated, the evolutionary origin of the cell nucleus, a milestone of eukaryotic evolution, remains unclear.”

    The origin of the eukaryotic nucleus must indeed be a milestone in the development of the cell itself, considering that it is the defining factor that sets eukaryotic cells apart from the other broad category of cells-the prokaryotic cell. The eukaryotic cell is neatly compartmentalized into membrane-bound organelles that perform various functions. Among them, the nucleus houses the genetic material. The other organelles float in what is called the cytoplasm. Prokaryotic cells do not contain such compartmentalization. Bacteria and archaea are prokaryotic cells.

    The 2001 hypothesis by Prof Takemura and PJ Bell is based on striking similarities between the eukaryotic cell nucleus and poxviruses: in particular, the property of keeping the genome separate in a compartment. Further similarities were uncovered after the discovery and characterization of a type of large DNA virus called “giant virus,” which can be up to 2.5 µm in diameter and contain DNA “encoding” information for the production of more than 400 proteins. Independent phylogenetic analyses suggested that genes had been transferred between these viruses and eukaryotic cells as they interacted at various points down the evolutionary road, in a process called “lateral gene transfer.”

    Viruses are “packets” of DNA or RNA and cannot survive on their own. They must enter a “host” cell and use that cell’s machinery to replicate its genetic material, and therefore multiply. As evolution progressed, it appears, viral genetic material became integrated with host genetic material and the properties of both altered.

    In 2019, Prof Takemura and his colleagues made another breakthrough discovery: the medusavirus. The medusavirus got its name because, like the mythical monster, it causes encystment in its host; that is, it gives its host cell a “hard” covering.

    © Copyright Original Source

    Glendower: I can call spirits from the vasty deep.
    Hotspur: Why, so can I, or so can any man;
    But will they come when you do call for them? Shakespeare’s Henry IV, Part 1, Act III:

    go with the flow the river knows . . .

    Frank

    I do not know, therefore everything is in pencil.

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