How the first (2p.2q) fused individual reproduced is certainly an open question. This link gives some ideas. Try to ignore that it's a "skeptic" site and read the substance.
http://www.skepticink.com/smilodonsr...ave-offspring/
http://www.skepticink.com/smilodonsr...ave-offspring/
Originally posted by From above link
Now, here’s where sstar’s question comes into play.
The first organism that had this mutation would have a different number of chromosomes than everyone else in the population and that presents a problem. For example, we all know that horses and donkeys breed and form sterile mules. Part of the reason that mules are sterile is that horses have 64 chromosomes and donkeys have 62. Wouldn’t this same issue occur with the first organism that had the combination mutation?
The answer is… not really.
The reason is that, unlike the horse/donkey hybrid, that first individual who had the fused chromosome 2p and 2q still has all of the genetic material of the rest of the population. Horses and donkeys do not have the same genetic material, they are closely related, but not in the same species. The process is called a balanced Robertsonian translocation.
Now, when meiosis occurs, the chromosomes are mixed and separated. One half of each chromosome comes from each parent. So, the parent with the fused chromosome can provide a couple of different versions of the chromosome(s).
A normal individual would have a pair of 2p and a pair of 2q chromosomes.
The affected individual has a single 2p, a single 2q, and a fused 2pq. Follow me so far?
Now, when meiosis occurs in a normal individual, the gamete will have a single 2p and a single 2q.
In our affected individual, the gamete could have
a single 2p and a single 2q – resulting in perfectly normal offspring
a single 2pq – resulting in perfectly normal offspring. All the genetic material is present, just in an odd shape and the other parent’s 2p and 2q chromosomes will link up nicely.
a 2p and the 2pq – this is bad. This is basically what happens in some versions of Down’s syndrome cases.
a 2q and the 2pq – this is also bad, the same as number 3.
So, in the case of that first individual with the fused 2pq chromosome, it had (probably several) offspring where the gamete formed was of the #2 variety. Just the fused chromosome and that’s all. This would result in perfectly normal offspring.
- See more at: http://www.skepticink.com/smilodonsr....sPvGachP.dpuf
The first organism that had this mutation would have a different number of chromosomes than everyone else in the population and that presents a problem. For example, we all know that horses and donkeys breed and form sterile mules. Part of the reason that mules are sterile is that horses have 64 chromosomes and donkeys have 62. Wouldn’t this same issue occur with the first organism that had the combination mutation?
The answer is… not really.
The reason is that, unlike the horse/donkey hybrid, that first individual who had the fused chromosome 2p and 2q still has all of the genetic material of the rest of the population. Horses and donkeys do not have the same genetic material, they are closely related, but not in the same species. The process is called a balanced Robertsonian translocation.
Now, when meiosis occurs, the chromosomes are mixed and separated. One half of each chromosome comes from each parent. So, the parent with the fused chromosome can provide a couple of different versions of the chromosome(s).
A normal individual would have a pair of 2p and a pair of 2q chromosomes.
The affected individual has a single 2p, a single 2q, and a fused 2pq. Follow me so far?
Now, when meiosis occurs in a normal individual, the gamete will have a single 2p and a single 2q.
In our affected individual, the gamete could have
a single 2p and a single 2q – resulting in perfectly normal offspring
a single 2pq – resulting in perfectly normal offspring. All the genetic material is present, just in an odd shape and the other parent’s 2p and 2q chromosomes will link up nicely.
a 2p and the 2pq – this is bad. This is basically what happens in some versions of Down’s syndrome cases.
a 2q and the 2pq – this is also bad, the same as number 3.
So, in the case of that first individual with the fused 2pq chromosome, it had (probably several) offspring where the gamete formed was of the #2 variety. Just the fused chromosome and that’s all. This would result in perfectly normal offspring.
- See more at: http://www.skepticink.com/smilodonsr....sPvGachP.dpuf
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