Originally posted by lee_merrill
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Originally posted by lee_merrill
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What i assume you're trying to mean is "more variation than would be expected from a pre-specified protein". And that is true. But this is where we get back to you not understanding the original argument. Which was that we have now idea how close any two proteins are to forming an interaction — as noted, it could be one mutation that's needed, it could be a half dozen. Given that, the only thing we can use to make inferences about the probability of their interactions is the general probability of protein protein interactions.
And this experiment suggests that probability is fairly high. On its own, it's only one piece of evidence. But, if you were to look into the scientific literature, you'd find out that there are lots of additional examples indicating that protein-protein interactions are quite common. And there are good biochemical reasons for that.
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